Crones Disease: Side Effects of Medicines: Summary
by Charlotte Kamman on 2007-09-24If you are taking medicines for your Crones disease, you will probably recognize a lot of the symptoms and side effects mentioned in this article. After a summary of the most problematic sides of mainstream medication, a possible solution is given to improve life quality and health in the long run on a solid basis.
Medicines are the most common Crones disease treatment. While none can cure this inflammatory bowel disease (IBD), they are used to try to reduce the swelling that causes the symptoms. The most frequently used medicines for Crones disease are Aminosalicylates and Corticosteroids to Block Inflammation, Antibiotics to Control Intestinal Bacteria, Immunomodulators to Calm the Immune System, and Biologic Therapies for Moderate or Severe Crones disease. Brand names of these medicines are (amongst others): - Aminosalicylates : Mesalamine (Asacol, Pentasa), Balsalazide (Dipentum), Olsalazine (Colazal) - Corticosteroids: Prednisone (Deltasone), Budesonide (Entocort EC) , Hydrocortisone, Methylprednisolone (Medrol) - Antibiotics: Ciprofloxacin (Cipro), Metronidazole (Flagyl) Immunomodulators: Azathioprine (Imuran, Azasan),6-mercaptopurine (Purinethol, 6-MP), Methotrexate (MTX, Rheumatrex, Mexate) , Tacrolimus (Prograf), Cyclosporine A (Sandimmune, Neoral) - Biologic Therapies: Infliximab (Remicade), Adalimumab (Humira).
I studied the medicines which doctors subscribe for Crones Disease. I discovered that most of them have mild to sever side effects, especially when taken for a longer period of time. Actually, if I realize that my body does not have time to recover and regain it's own balance after taking a course of medicine, I start to see the course this whole thing is going to take... :-( Side effects are (amongst others): Diarrhea Headache, dizziness Increased risk of bleeding in the gastrointestinal tract Indigestion, nausea, gas Hair loss Rash Decrease in white blood cells High blood pressure Mood swings, psychosis, insomnia Weight gain, moon facies Acne, increased facial hair, stretch marks Increased risk of infection Osteoporosis Vomiting Cough Sinus infections Sore throat
Enemas and Suppositories can be used to apply the medicines more locally and targeted. Biologic therapies are applied by frequent injections. Needless to say that this will have a major impact on your social life.
I want to make a special note on corticosteroids. Some corticosteroids can also be given intravenously. Corticosteroids can have severe side effects, like an increased risk of infection, so even the mainstream doctors will hesitate to prescribe them for a longer period of time. If you want to stop taking corticosteroids, make sure you taper off them gradually. Stopping them suddenly can worsen side effects.
Antibiotics are known to be bad for you intestines. Even my vet prescribes probiotics to my dog if she has to take antibiotics to maintain the level of good bacteria in the gut as high as possible. If you take antibiotics over a longer period of time, or you take antibiotics with regular intervals, your natural bacteria level in your gut will be very low; good bacteria and bad bacteria. If you have a low level of good bacteria, your gut is missing it's natural shield against attacks of bad bacteria, and the question is if this actually is not worsening the overall situation.
Injectable or oral immunomodulators are used if the patient did not react well on other medicines to reduce the swelling, or for patients which developed complications like fistulas. Often they are given in combination with corticosteroids, whereby you can take lower doses of the latter, because their effect is increased by the immunomodulators. Immunomodulators are more expensive than other medicines used for Crones Disease, and you are at higher risk to develop secondary infections or other illnesses because they suppress the immune system. Doctors advise you to have your blood monitored regularly to see the effect on your bone marrow, liver and kidneys.
The newest and most expensive treatment for Crones Disease is Biological therapy. It can be used to improve the symptoms, but will have to be taken on the long run to avoid backfalls. At the moment it is only used for patients which do not respond to other treatments, as the side effects can be severe. It suppresses the immune system and hence makes us prone to infections. There is even evidence that it increases the risk of conditions like blood infections, tuberculosis, and lymphoma.
Often Crones Disease will cause diarrhea, and you will have to take medicines to compensate for the fluid loss and to stop the diarrhea. Some of the mentioned medicines can interact with common drugs like birth control pills, antacids, and even vitamins.
If we recap all the information in this article, it is clear that an alternative approach to Crones Disease is dearly wanted. Improving the natural balance of bacteria in our gut would be helpful to start with, and a general improvement of our overall immune system is vital. If we find a additional treatment which helps us to reach these goals, we could start to use it as a way to help our body to regain it's natural strength, and eventually the new approach could take over the treatment using medicines.
About The Author: Crones Disease is a "uncurable" disease which has a big impact on the patient and his family. Side effects of medicines can make life more complicated; here you will find an alternative to help your body overcome your Crones Disease.